Little Known Facts About phenobarbital sodium water solubility.
Little Known Facts About phenobarbital sodium water solubility.
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pentobarbital decreases effects of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Coadministration of CYP3A4 inducers could lessen sufentanil concentrations and efficacy, maybe precipitating withdrawal syndrome in clients who definitely have designed Bodily dependence to sufentanil. Discontinuation of concomitantly used CYP3A4 inducers may well boost sufentanil plasma concentration.
Contraindicated (1)pentobarbital will lower the extent or effect of doravirine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
Animal data. Phenobarbital sodium is carcinogenic in mice and rats soon after lifetime administration. In mice, it created benign and malignant liver mobile tumors. In rats, benign liver mobile tumors ended up noticed pretty late in life.
benzhydrocodone/acetaminophen and pentobarbital the two enhance sedation. Steer clear of or Use Alternate Drug. Limit use to sufferers for whom alternative treatment choices are inadequate
pentobarbital will lessen the extent or effect of midostaurin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Sturdy CYP3A4 inducers may lessen midostaurin concentrations causing lessened efficacy.
pentobarbital will reduce the extent or effect of gefitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
Monoamine oxidase inhibitors (MAOI): MAOI extend the effects of barbiturates probably due to the fact metabolism with the barbiturate is inhibited.
Keep track of Closely (1)pentobarbital will lower the level or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
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pentobarbital will minimize the extent or effect of loratadine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will decrease the level or effect of celecoxib by influencing hepatic enzyme CYP2C9/10 metabolism. Insignificant/Significance Not known.
pentobarbital will lower the extent or effect of rabeprazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unknown.
Keep track of Intently (one)pentobarbital will reduce the level or effect of benzhydrocodone/acetaminophen by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Caution when discontinuing CYP3A4 inducers that are coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone may perhaps boost and can result in most likely lethal respiratory depression.
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